Ronald Colman

Dr. Martin Arrowsmith

Helen Hayes

Leora Tozer Arrowsmith

Richard Bennett

Gustav Sondelius

A.E. Anson

Professor Max Gottlieb

Clarence Brooks

Dr. Oliver Marchand

Alec B. Francis

Twyford

Claude King

Dr. Tubbs

Bert Roach

Bert Tozer

Myrna Loy

Joyce Lanyon

Russell Hopton

Terry Wickett

David Landau

State Veterinarian

Lumsden Hare

Sir Robert Fairland

Erville Alderson

Pioneer (uncredited)

Ward Bond

Cop (uncredited)

Beulah Bondi

Mrs. Tozer (uncredited)

Florence Britton

Miss Twyford (uncredited)

Nora Cecil

Nurse (uncredited)

Sidney De Gray

Dr. Hesselink (uncredited)

Cyril Delevanti

Committee Member (uncredited)

Walter Downing

City Clerk (uncredited)

Gibson Gowland

Committee Member (uncredited)

Sherry Hall

Reporter (uncredited)

Theresa Harris

Native Mother (uncredited)

Raymond Hatton

Drunk (uncredited)

Charlotte Henry

Pioneer Girl (uncredited)

George Humbert

Italian Uncle (uncredited)

DeWitt Jennings

B.W. Tozer (uncredited)

Mike Lally

Reporter (uncredited)

Lillian Lawrence

West Indies Townswoman at Meeting (uncredited)

Carl M. Leviness

Ship's Passenger (uncredited)

James A. Marcus

Old Doctor (uncredited)

Eric Mayne

Dignitary at Luncheon (uncredited)

Kendall McComas

Little Johnny (uncredited)

Edmund Mortimer

Ship's Passenger (uncredited)

John Qualen

Henry Novak (uncredited)

Edward Reinach

Dignitary (uncredited)

Milton Royce

Intern (uncredited)

Harry Schultz

Bartender (uncredited)

Pat Somerset

Ship's Officer (uncredited)

Adele Watson

Mrs. Novak (uncredited)