Ryan Reynolds

Wade Wilson / Deadpool / Juggernaut (voice)

Josh Brolin

Cable

Morena Baccarin

Vanessa

Julian Dennison

Firefist

Zazie Beetz

Domino

T.J. Miller

Weasel

Leslie Uggams

Blind Al

Karan Soni

Dopinder

Brianna Hildebrand

Negasonic Teenage Warhead

Jack Kesy

Black Tom

Eddie Marsan

Headmaster

Shioli Kutsuna

Yukio

Stefan Kapičić

Colossus (voice)

Randal Reeder

Buck

Nikolai Witschl

Head Orderly Frye

Thayr Harris

Sergei Valishnikov

Rob Delaney

Peter

Lewis Tan

Shatterstar

Bill Skarsgård

Zeitgeist

Terry Crews

Bedlam

Brad Pitt

Vanisher

Paul Wu

Hong Kong Boss

Robert Maillet

Sluggo

Alan Tudyk

Luke - Redneck #1

Matt Damon

Redneck #2

Michasha Armstrong

Swat Captain (School)

Joe Doserro

Bus Driver

Hayley Sales

Cable's Wife

Islie Hirvonen

Cable's Daughter

Jagua Arneja

Tree Trimmer #1

Gerry South

Tree Trimmer #2

Mike Dopud

Prison Guard

Luke Roessler

Cereal Kid

Andy Canete

Neighbor #1

Tanis Dolman

Neighbor #2

Eleanor Walker

Neighbor #3

Hunter Dillon

Branding Boy

Sala Baker

Older Firefist

Sonia Sunger

News Reporter (Irene)

Paul Wernick

News Cameraman